While miR-25 and miR-448-3p reduce ROS levels by targeting nicotinamide adenine dinucleotide phosphate oxidase (NOX) [110, 111], tumor-associated fibroblasts (cancer-associated fibroblasts, CAFs) inhibit the ferroptosis in cancer cells by secreting exosomal miR-522 to target ALOX15 and blocking the accumulation of lipid ROS [112]. The gene discussed is ALOX15; the disease is cancer.