CTCF and Intellectual disability: Among these TF were several that have previously been associated with neurodevelopmental disorders: Firstly, the Transcriptional repressor CTCF, which can bind to CpG m1001, has been shown to play a role in neurodevelopmental processes and has been linked to characteristics also seen in the PWS phenotype such as intellectual disability, behavioral challenges, feeding difficulties and growth restriction [49–51].