Many of the top DE genes of archetype 5 (see MCF-7 DEGs in Supplemental Data 1), including GPRC5A, ITGAV, SEMA3C, and ITGB6, have been proven to associate with breast cancer susceptibility to apoptosis or treatment and poor prognosis (Moore et al, 2014; Zhou & Rigoutsos, 2014; Malik et al, 2016; Cheuk et al, 2020). This evidence concerns the gene GPRC5A and breast cancer.