MAPT and Alzheimer disease: More recently, lipids extracted from a range of sources of amyloid fibril, including AA, ATTR, Aβ2M, ALλ, and ALκ amyloidoses (66), a group of conditions resulting from a build-up of amyloid in particular organs and tissues, and AD (paired helical filaments of tau (67)), have been analyzed by high-performance TLC and MS.