Our receptor-ligand interaction analysis between tumor/stroma and immune cells revealed several genes that have already been correlated with NB growth and differentiation,72, 73, 74,84 as well as the discovery of important cell-cell interactions mediating immune suppression in other cancer types, such as the CCL20-CCR6 axis in prostate cancer bone metastasis32 and the CD161-CLEC2D axis in glioma.85 This evidence concerns the gene CLEC2D and Familial prostate cancer.