CLIC2 and neoplasm: This cancer-specific rewiring of the stroma goes from an ASPN+ state (FIB I) to a CLIC2+ (FIB II) and CEMIP+ (FIB III) state found sparingly around KRT14+ tumor nests, before reaching the TMEM119+/WNT5A+ state (FIB IV) that surrounds KRT14+ tumor nests at a relatively high density compared to the other three FIB states (Fig. 3, E to H and M).