Our in situ imaging analysis suggests that TMEM119+ FIBs segregate distinctly across KRT14+ tumor nests in terms of both position and density, further reinforcing the notion that significant intertumoral FIB heterogeneity exists in human BCC and that this particular population may be functionally and structurally positioned to support tumoral growth and progression. This evidence concerns the gene TMEM119 and skin basal cell carcinoma.