We identified 10 coarse-grained cell types based on bona fide biomarkers, which included MKI67+ proliferative epithelial cells, KRT14+ basal epithelial/tumor cells, terminally differentiated IVL+ keratinocytes, AZPG+ appendage-associated cells, PDGFRA+ fibroblastic cells, RGS5+ FIB-like cells, TIE1+ endothelial cells, PROX1+ lymphatic endothelial cells, MLANA+ melanocytic cells, and immune cells identified by expression of PTPRC (Fig. 1B). This evidence concerns the gene TIE1 and neoplasm.