CXCL signaling is contained within FIBs in PTS but expands to the BAS cell clusters in BCC (Fig. 5F); IL6 signaling shows greater cross-talk in BCC compared to PTS (Fig. 5G); IFN-I signaling is contained within epithelia in PTS but expands to FIBs in BCC (Fig. 5H); and TNF signaling is exclusive to BCC (Fig. 5I). The gene discussed is TNF; the disease is skin basal cell carcinoma.