LHX2 and skin basal cell carcinoma: LHX2 is significantly expressed in bulk-level RNA-seq data from vismodegib-sensitive and vismodegib-resistant advanced BCC tumors compared to normal skin with ACTA2 showing tumor-specific variability and KRT15 not showing significance (28), reinforcing the heterogeneity of BCC tumors and highlighting how single-cell data can resolve significantly expressed genes that are otherwise averaged out in bulk-level RNA-seq studies.