This was confirmed in a logistic regression analysis after adjustment for previously established factors associated with thyroid functional outcome after RAI: age, degree of thyrotoxicosis, TSH-R Ab titer, thyroid volume, pre-RAI therapy with ATD, and RAI activity (3, 4, 5, 6, 7, 19, 21, 22). The gene discussed is TSHR; the disease is thyrotoxicosis.