In models of breast cancer, we previously found that TBX2 binds to and represses the proximal promoters of tumour suppressors N-Myc Downstream Regulated 1 (NDRG1) and Cystatin 6 (CST6), without the requirement for a T-Box element; instead TBX2 binds DNA indirectly via interaction with EGR1 at these genetic loci. The gene discussed is CST6; the disease is breast cancer.