MYCN and neoplasm: Kinase enrichment analysis of promoters bound by TBX2 in both cell lines found EGFR downstream targets to be specific to MCF7, while promoters of genes regulated by CDK7 were specific to the Kelly cell line; this was fitting given that CDK7 is known to be a key driver of N-Myc-dependent super-enhancer activity in tumours with N-Myc amplification (41) (Supplementary Figure S8C).