Initially a viability screen was performed in TBX2-dependent MCF7 and T47D breast cancer models, employing an endoribonuclease siRNA (esiRNA) library of 56 known epigenetic modifiers; any resulting ‘hits’ whose knockdowns reduced cell viability could represent potential functional interactors of TBX2 (Figure 1A). The gene discussed is TBX2; the disease is breast carcinoma.