TBX2 sites which were unique to Kelly cells, however, exhibited a strikingly different profile with the majority of binding falling into intragenic and intergenic regions (Supplementary Figure S8B), indicative of the strong participation of TBX2 in deregulated enhancer circuitry of N-Myc neuroblastoma previously described (4,10). Here, TBX2 is linked to neuroblastoma.