More recently, TBX2 was found to function as a transcriptional activator in MYCN-amplified neuroblastoma, where it participates in a super-enhancer-driven positive feedback loop, promoting the expression of core regulatory circuitry components HAND2, ISL1, PHOX2B and GATA3 to maintain a viable cell state (10). The gene discussed is TBX2; the disease is neuroblastoma.