TBX2 target genes (NDRG1, CST6) did not show consistent upregulation in other TBX2 non-expressing breast cancer lines following knockdown of TBX2, LSD1 or ZNF217, further confirming the requirement for TBX2 in recruiting the CoREST complex to promoters (Supplementary Figure S5). Here, CST6 is linked to breast cancer.