80). At present, there is a lack of consensus on recommendations for the use of these drugs during pregnancy. Hence, it is a big challenge to carefully weigh the benefits and risk of anti-TNF-α drugs exposed to the mother and infant. The problem and puzzle about anti-TNF-α drug on the pregnancy outcome are whether the drug induces infertility (Ref. 1); whether the drug causes adverse pregnancy outcomes in different time of conception (Ref. 2); whether the drug can lead to foetal abnormalities and other potential complications (Ref. 3). Here, TNF is linked to Infertility.