CeAD had the largest number of downregulated proteins in the acute phase (in red; Figure 3A), and several of these proteins were significantly elevated in another subtype (eg, CD5 in cryptogenic stroke; IL-12B and TNFRSF9 in SAO and cryptogenic stroke; and TRANCE in LAA, SAO, and cryptogenic stroke). This evidence concerns the gene CD5 and southeast Asian ovalocytosis.