ACE2 and sickle cell disease: This low expression of ACE2 is hypothesized to offer genetic advantage like the novel resistance locus close to the cluster of genes that code for glycophorins (plasmodium falciparum erythrocyte invasion receptor), heterozygosity for sickle cell anemia, or resistance to Plasmodium Vivax infection due to the preponderance of Duffy blood group-negative individuals in Africa [33-35].