TGFB1 and cancer: Tumor cells escape these antiproliferative control by loss of function of these genes or alterations in response to their close regulators as TGFβ or immediate downstream targets of its action, as CDK4 and its inhibitory proteins [75] and contact inhibition of cell growth, like NF2 / Merlin and LKB1 epithelial polarity protein, that when disrupted can also facilitate uncontrolled proliferation as seen in cancer tissues [1].