Also, autophagy provides tumor cells the ability to avoid anoikis, a process of detachment-induced programmed cell death, resulting from loss of, or inappropriate cell adhesion from the extracellular matrix (ECM) via RNA-like endoplasmic reticulum kinase (PERK), that promotes autophagy and ROS detoxication in mammary epithelial cells [13], upregulation of BNIP3 mediated by ERK/HIF-1α pathway induced autophagy by suppressing mTOR/S6K1 [14] and deficiency of miRNA-30a, a tumor suppressor that targets Beclin-1 and ATG5 in hepatocellular carcinoma [15]. This evidence concerns the gene HIF1A and neoplasm.