Although not totally clear, some studies suggest a positive correlation between autophagy and epithelial-mesenchymal transition (EMT), which is needed in cancer progression and metastasis, probably via p62 (an autophagy adaptor protein) and tumor growth factor β (TGF-β), which is the most important regulator of EMT in human cancers [10]. The gene discussed is TGFB1; the disease is cancer.