It causes the production of angiogenetic factors such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, transforming growth factor α, TGF-β, tumor necrosis factor (TNF)-α etc. by cancer cells, which bind to endothelial cell receptors of the vessels and initiate above mentioned process. Here, FGF2 is linked to cancer.