The key elements of these guidelines are as follows: the diagnosis of PBC is confirmed by two of the following criteria - (1) persistent, unexplained cholestatic liver biochemistry; (2) detection in the serum of anti-mitochondrial antibodies (AMA) or the PBC-specific anti-nuclear antibodies (ANA), anti-Sp100 and anti-gp210 antibodies; or (3) liver biopsy features compatible with PBC [1]. Here, BTG3 is linked to primary biliary cholangitis.