In addition, another entity, called “double-expressor lymphoma” (DEL) (5, 6), has been identified based on MYC and Bcl-2 protein overexpression by IHC without gene aberrations (MYC and Bcl-2 and/or Bcl-6 rearrangements) by FISH, with positive cut-off values for MYC+ of ≥40% and Bcl-2+ of ≥50% in most studies (7, 8). This evidence concerns the gene BCL2 and lymphoma.