Currently, HGBL is subgrouped as HGBL with MYC and Bcl-2 and/or Bcl-6 rearrangements, so-called double- or triple-hit lymphoma (HGBL-DH or HGBL-TH, respectively) (2) and as HGBL, not otherwise specified (HGBL-NOS), which lacks MYC and Bcl-2 and/or Bcl-6 rearrangements. The gene discussed is BCL2; the disease is high grade B-cell lymphoma.