HGBL is comprised of two types, i.e., HGBL with MYC and Bcl-2 and/or Bcl-6 rearrangements (HGBL-DH or HGBL-TH) and HGBL-NOS, which replaced the category of B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and BL (BCLU). This evidence concerns the gene BCL6 and diffuse large B-cell lymphoma.