Among 72 out of the 187 patients who achieved first CR, six cases with HGBL (including 4 cases of MYC-Bcl-6 HGBL-DH, one case of HGBL-TH, and one case of HGBL-NOS) and 17 cases with non-HGBL relapsed during maintenance treatment after the first remission. The gene discussed is TH; the disease is high grade B-cell lymphoma.