Compared to previous studies showing the effect of pan-PAD chemical inhibitors in ameliorating lupus in MRL/lpr mice (23) and of PAD4 and PAD2 deficiency in preventing lupus in FVB mice (24), PAD4 deficiency in MRL/lpr mice and pan-PAD chemical inhibitors in Fas/lpr did not improve lupus (54). Here, FAS is linked to systemic lupus erythematosus.