In the Fc gamma receptor 2b deficient (Fcgr2b-/-) mouse model of lupus, renal ischemia reperfusion injury promoted NETs in peripheral blood neutrophils and kidneys, which was followed by glomerular immunoglobulin (Ig) deposition and increased serum anti-dsDNA Ab. This evidence concerns the gene FCGR2B and systemic lupus erythematosus.