The present study shows, for the first time, that two months after SARS-CoV-2 infection, the COVID-19 group with SIgA showed increased salivary SIgA levels than the control group with SIgA, as well as pro-inflammatory cytokines, such as IL-12p70, IL-13, IL-17A, IFN-α, and IFN-γ, and the anti-inflammatory cytokine IL-10, as compared to the other groups. Here, IFNG is linked to COVID-19.