IFNG and viral infectious disease: It is noteworthy to point out that regardless of the type of interferons [type-I (IFN-α and IFN-β); type II (IFN-γ); or type-III (IFN-λ)], in a viral infection, these molecules are the main antiviral cytokines that promote the infection control and the ability to elicit an adaptive immune response to improve the viral clearance (70).