In a previous report, we performed bulk and single-cell RNA-sequencing (scRNA-seq) of peripheral blood immune cells from SSc and identified a SSc-related inflammatory gene module and a cluster of monocytes, similar to lung-infiltrating FCN1hi monocytes expressing IL1B. This study included SSc patients with relatively long disease durations, therefore we estimated that monocyte/macrophage subsets were important for SSc pathogenesis during the disease course (22). Here, IL1B is linked to systemic sclerosis.