A study has shown that SMPDL3A is highly expressed in bladder cancer and directly interacts with a tumor suppressor gene, i.e., deleted in bladder cancer chromosome region candidate 1 (DBCCR1) (24) SMPDL3A is also used as an indicator to evaluate the prognosis of colon cancer and may become a target for the diagnosis and treatment of colon cancer in the future (25). The gene discussed is SMPDL3A; the disease is malignant colon neoplasm.