VDAC1 and hepatocellular carcinoma: To further study the role of downstream related molecules of VDAC1, we utilized the Affymetrix GeneChip system to analyze the downstream gene expression profile of VDAC1 and showed 522 differentially expressed genes (DEGs) in HCC cells after knocking down VDAC1. Based on these findings, and combined with other literature, 17 representative DEGs were selected for further high-throughput functional screening based on cell proliferation.