Combined to the clinicopathological data of the patients, the results of t-test and chi-square test showed that SMPDL3A expression was closely related to the vitamin K absence-II (PIVKA-II) level, liver cirrhosis, tumor diameter, microvascular invasion, and BCLC staging of the patients (P < 0.05, Table 1). The gene discussed is SMPDL3A; the disease is cirrhosis of liver.