By dividing the cohort into two groups through the cutoff value of CPN2 protein expression as mentioned above, we found that the CPN2 expression status was significantly associated with lymph node status (P = 0.006), pathological N stage (P = 0.011), and American Joint Committee on Cancer (AJCC) stage (P = 0.035), but not with age, gender, grade, tumor size, total lymph nodes, pathological T stage, or pathological M stage (Table 1). Here, CPN2 is linked to neoplasm.