TP53 and autosomal dominant cerebellar ataxia: Studies have shown that loss of heterozygosity (LOH) of TP53 and ESR is higher in ovarian serous cystadenocarcinoma (SCA) and more common in clear cell carcinoma (CCA) and serous tumor with low malignant potential (SLMP), which has been observed in primary ovarian tumors and metastases (65).