The rearrangement of the RNA-binding protein EWSR1 characterizes a variety of malignant tumors, including Ewing’s sarcoma (EWSR1/ETS), depilated small round cell tumor (EWSR1/WT1), and some acute lymphoblastic leukemia (EWSR1/ZNF384) (67). The gene discussed is EWSR1; the disease is Ewing sarcoma.