Many of the DEGs were involved in synapses, ion channels, neurons, and ECM, demonstrating that our sv2a loss-of-function zebrafish model mimics aspects of human epilepsy (Okamoto et al., 2010; Winden et al., 2011; Pitkanen et al., 2015; Engel and Pitkanen, 2020). Here, SV2A is linked to epilepsy.