To understand how zebrafish larvae lacking sv2a compare with other previously established zebrafish epilepsy models, the sv2a–/– transcriptome was compared to the transcriptomes of five zebrafish epilepsy models: gabra1 (Samarut et al., 2018) recapitulating idiopathic generalized epilepsy, depdc5 (Swaminathan et al., 2018) and tsc2 (Scheldeman et al., 2017) modeling mTORopathies, scn1lab (unpublished data) recapitulating Dravet syndrome, and kainic acid-injected (unpublished data), a chemically-induced larval epilepsy model. This evidence concerns the gene DEPDC5 and idiopathic generalized epilepsy.