While elevated ErbB signaling is associated with chronic inflammatory disorders, EGFR helps mount innate immune responses and epidermal loss of EGFR or EGFR receptor inhibitors used in cancer treatment elicit adverse inflammatory rashes (Pastore et al., 2008; Lichtenberger et al., 2013; Mascia et al., 2013; Huang et al., 2021). The gene discussed is EGFR; the disease is cancer.