Further inspection of the top differentially expressed genes for LR and LRI showed a strong downregulation of Caveolin-3 (CAV3) that has been implicated in the biogenesis of t-tubules (33) and moreover been shown to be associated with cardiac hypertrophy and heart failure when expression is decreased (34) (Figures 1E,F). The gene discussed is CAV3; the disease is cardiac hypertrophy.