KLK3 and benign prostatic hyperplasia: Although the association between the density of prostate-specific antigen (PSA), benign prostatic hyperplasia (BPH), and PCa is consolidated in the literature [6, 7], several studies involving potentially more sensitive and specific biomarkers have been developed with the aim of improving the detection and monitoring of these pathologies and eliminating the limitations inherent to PSA [8, 9].