MAPT and Alzheimer disease: A decrease in NAA/Cr ratio accompanied by an increased mINS/Cr ratio occurs in patients with AD; the latter temporal progression of metabolite abnormalities in patients with AD correlates with the progression of the Aβ/tau-linked alterations (Glanville et al., 1989; Klunk et al., 1992; Miller et al., 1993; Bitsch et al., 1999; Jessen et al., 2000; Kantarci et al., 2000, 2007; Huang et al., 2001; Cheng et al., 2002; Schott et al., 2010).