NOS2 and Alzheimer disease: Likewise, we have previously observed that 3-month treatment of um-PEA almost completely abolishes the increase in inflammatory markers observed in 6-month-old 3 × Tg-AD mice and suppresses the expression of proinflammatory mediators, including interleukin (IL)-1β, IL-16, IL-5, monocyte chemotactic protein 5 (MCP-5), and macrophage colony-stimulating factor (M-CSF), but not inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF), while enhancing the anti-inflammatory IL-10 (Scuderi et al., 2018).