ALB and Alzheimer disease: Ng et al. (2008) also found that poor cognitive performance increased with decreasing quintiles of albumin, and multivariate analyses showed that the lowest quintile of albumin was associated with a twofold increased risk of poorer cognitive performance, independent of other nutritional or risk factors. In the existent research on albumin concentrations and dementia, Kim et al. (2006) found significant reductions in albumin concentrations in AD patients compared to controls.