In this respect, G6PD-deficient neonates monitored in the hospital during the first week of life that have an enzyme activity below 6.76 U/g Hb or the G6PD Kaiping (c.1388G > A) variant are associated with significant hyperbilirubinemia requiring phototherapy intervention (14). The gene discussed is G6PD; the disease is Hyperbilirubinemia.