On the basis of network topology algorithm, all core target genes in VA against As-linked dermatitis were reported, including JUN, TP53, MAPK3, MAPK1, MAPK14, IL6, AKT1, STAT1, FOS, ESR1, TNF, CREB1, IL10, IL2, SP1, CASP3, CDKN1A, IL4, EGFR, IL1B, MCL1, BCL2, CXCL8, TGFB1, IFNG, BCL2L1, NOS2, CCL2, and VEGFA (Figure 2). Here, CCL2 is linked to skin disorder.