As shown in all core targets, JUN, TP53, MAPK3, MAPK1, MAPK14, IL6, AKT1, STAT1, FOS, ESR1, TNF, CREB1, IL10, IL2, SP1, CASP3, CDKN1A, IL4, EGFR, IL1B, MCL1, BCL2, CXCL8, TGFB1, IFNG, BCL2L1, NOS2, CCL2, and VEGFA were identified to be virtually associated with As-related dermatitis. The gene discussed is CREB1; the disease is dermatitis.