They can improve insulin resistance (35) and reduce hepatic lipids and serum endotoxin levels, which may be associated with the stimulation of expression of adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) and serine/threonine kinase (AKT) proteins, and lipogenesis- or lipolysis-related proteins (36). The gene discussed is MARK2; the disease is Insulin resistance.