These 16 hub genes, TFDP1, KRAS, LMNB1, MET, MYBL2, CDC25A, E2F5, HMGA1, HMGA2, CBFB, CBX3, CDC7, IGF2BP3, KIF11, PDGFB, and SMC1A were all upregulated in GC tissues compared with adjacent tumor-free gastric tissues. The gene discussed is KIF11; the disease is gastric cancer.