These 16 hub genes, TFDP1, KRAS, LMNB1, MET, MYBL2, CDC25A, E2F5, HMGA1, HMGA2, CBFB, CBX3, CDC7, IGF2BP3, KIF11, PDGFB, and SMC1A were all upregulated in GC tissues compared with adjacent tumor-free gastric tissues. Here, TFDP1 is linked to gastric cancer.