These 16 hub genes, TFDP1, KRAS, LMNB1, MET, MYBL2, CDC25A, E2F5, HMGA1, HMGA2, CBFB, CBX3, CDC7, IGF2BP3, KIF11, PDGFB, and SMC1A were all upregulated in GC tissues compared with adjacent tumor-free gastric tissues. This evidence concerns the gene HMGA1 and gastric cancer.