For example, Zhang et al. indicated that overexpression of has_circ_0032627 was associated with poor survival in patients with GC, and has_circ_0032627 knockdown contributed to the inhibition of GC metastasis via inactivating the NRAS/MEK1/ERK1/2 signaling pathway and regulating the miR-502-5p expression [28]. The gene discussed is MAP2K1; the disease is gastric cancer.