CNR2 and Alzheimer disease: The CB2 radiotracers [11C]A-836339 have been tested in the LPS-induced neuroinflammation mouse model and the Appswe/PS1/dE9 mouse model (Horti et al., 2010), while [18F]JHU94620 has been tested in the LPS-induced neuroinflammation mouse model, which shows high-affinity binding to CB2R and sufficient selectivity over CB1R. A few tracers targeting caspase 3 and aspartryl capthepsin have been tested in AD model mice, with the majority of the tracers mainly tested in human subjects.