Case 2 had a likely pathogenic variant in DEPDC5 (a gene associated with familial epilepsy) on molecular genetic testing, although the role of this in the death of the infant was uncertain [of note, we did find ectopic neurons in the hippocampus, as has been seen in sudden unexpected death in toddlers with personal or family histories of febrile seizures (18). Here, DEPDC5 is linked to Seizure.