Compared with the non-ISR group, the ISR patients had a significantly higher proportion of diabetes mellitus, longer stent implantations, higher serum hs-CRP, HMGB1 concentrations, longer stent lengths, and smaller lumen diameters (Table 1), No correlation was observed between ISR occurrence and age, gender, smoking history, diabetic history, location of the lesion, or hypertension drugs. Here, HMGB1 is linked to hypertensive disorder.