Extracellular deposition of polymerized amyloid-β (Aβ) protein, also called plaques, and intracellular filamentous inclusions of hyperphosphorylated tau protein, known as neurofibrillary tangles, are the two major neuropathology involved in Alzheimer’s disease (AD) (Yamaguchi et al., 1989; Lee et al., 1991). This evidence concerns the gene MAPT and Alzheimer disease.