Induction of the intrinsic and extrinsic apoptosis pathways by curcumin occur via suppression of COX2 through deregulation of NF-kB, downregulation of Bcl-2 and upregulation of Bax and Bad proteins in lung cancer cells; suppression of the PI3K/Akt/mTOR pathway and enhanced Fas/CD95 expression and caspase-8 activity (extrinsic apoptotic pathway activation) have been observed (Wan Mohd Tajuddin et al., 2019). The gene discussed is FAS; the disease is lung cancer.