The different effects of curcumin in normal cells or cancer cells have not been fully clarified, but some reasons have been suggested, such as a higher uptake and lower glutathione levels in tumor cells as compared to normal cells as well as costitutive NF-kB activation in most tumor cells (Syng-Ai et al., 2004; Shishodia et al., 2005; Kunwar et al., 2008). The gene discussed is NFKB1; the disease is cancer.