LRP6 and neoplasm: Curcumin down-regulated Wnt/β-catenin signaling by suppressing Wnt3a and low-density lipoprotein receptor-related protein 6 (LRP6) phosphorylation - an event critical for the activation of the pathway - as well as downstream target genes contributing to tumor growth, such as c-myc (Zheng et al., 2017).