In fact, Ku et al. (2018) mentioned that morphological changes in the skin lesions of DNCB-sensitized mice revealed some of the major histopathological findings associated with human AD such as thickened epidermis, massive infiltration of CD4+ T-cells producing pro-inflammatory cytokines as well as increased infiltration of inflammatory cells i.e., mast cells and eosinophils. This evidence concerns the gene CD4 and Alzheimer disease.