With the expression of a Th2-skewed immunity, AD patients tend to exhibit an increase in cytokine expression, with interleukins 4 and 13 (IL-4 and IL-13) being the two pivotal cytokines that orchestrate the pathogenesis of this disease as well as elevated levels of high-affinity IgE receptor known as Fc epsilon receptor I (FcεRI). The gene discussed is IL4; the disease is Alzheimer disease.