As a major evasion mechanism at this stage, cancer cells reduce the expression of CXCR3 ligands such as CXCL9, CXCL10, and CXCL11, and/or carry out posttranslational modification or decomposition of CXCR3 ligands, thereby inhibiting the migration of CD8+ T cells to the tumor (Karin, 2020). Here, CD8A is linked to neoplasm.