CD274 and cancer: The expression of PD-L1 in cancer cells induced by EMT consequently evaded attacks on CD8+ T cells (Dongre et al., 2017; Noman et al., 2017), increasing cancer metastasis, which was shown to inhibit immune response even in EMT occurred NSCLC patients through increased expression of various immune checkpoint proteins and increased Treg (Celià-Terrassa et al., 2012; Tripathi et al., 2016).