For example, Egland et al. observed in pancreatic cancer tissues samples the expression of the γ1 protein LRRC26 (also known as CAPC), which left-shifts the voltage-dependence of the channel activation to more hyperpolarized voltages (Egland et al., 2006; Gonzalez-Perez et al., 2022). The gene discussed is LRRC26; the disease is familial pancreatic carcinoma.