TP53 and colorectal cancer: In colorectal cancer cells with high expression of DPP4, p53 binds and isolates DPP4 via ribozyme inactivation; this causes dissociation of NADPH oxidase one and nuclear translocation of DPP4, leading to diminished lipid peroxidation and abrogation of ferroptosis-promoting activity (Xie et al., 2017).