Ascorbate possesses various protective cardiovascular effects, ranging from anti-oxidative and anti-inflammatory, and may decrease plasma levels of tissue plasminogen activator (tPA) and von Willebrand factor (vWF) as well as affect thrombosis/fibrinolysis system in patients with type 2 diabetes and coronary artery disease [40, 41]. This evidence concerns the gene PLAT and type 2 diabetes mellitus.