For example, a trial conducted on 90 pregnant women with gestational diabetes mellitus (GDM) for 6 weeks to survey the effect of synbiotic supplementation—consisting of L. acidophilus, L. plantarum, L. fermentum, and L. gasseri (1.5–7.0 × 109-10 CFU/g)—with fructooligosaccharide (38.5 mg) on insulin resistance and lipid profile did not show a significant reduction in TC plasma levels [38] which may be due to the shorter intervention period and physiological status of subjects who were pregnant. This evidence concerns the gene INS and gestational diabetes.