Early studies showed that the plasma concentrations of gefitinib and erlotinib, two commonly used EGFR-TKIs, were significantly lower in NSCLC patients with concomitant AS compared to those without AS [8, 9], which raised the hypothesis that coadministration of EGFR-TKIs with AS may compromise the efficacy of TKIS in patients with NSCLC [10]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.