It has been demonstrated that obesity and inflammation have a strong relationship, such that excessive fat mass can lead to an inflammatory response and increase markers of inflammation, such as transforming growth factor beta 1 (TGF-β1), interleukin-β1 (IL-β1), and monocyte chemoattractant protein-1 (MCP-1). This evidence concerns the gene CCL2 and obesity due to melanocortin 4 receptor deficiency.