EXT1 may affect tumor survival by activating the Wnt signaling pathway (Kong et al., 2021), and it has also been demonstrated that KIF2C is activated by the Wnt signaling pathway and thus can promote liver cancer progression by activating mTORC1 signaling (Wei et al., 2020), so we speculate that EXT1 may influence KIF2C and thus promote tumor development. The gene discussed is KIF2C; the disease is neoplasm.