The prognostic analysis revealed that KIF2C was negatively correlated with the OS of ACC, KIRC, KIRP, LGG, LIHC, MESO, and UCEC, and positively correlated with the OS of THYM only, which, combined with the results of Cox regression analysis, can be considered as a prognostic marker in several cancers. Here, KIF2C is linked to adrenal cortex carcinoma.