More than 30 ICP genes were associated in with KIRC, UCEC, LGG, and GBM.KIF2C was positively correlated with ICP genes in BLCA, BRAC, HNSC, KICH, KIRC, KIRP, LGG, LIHC, MESO, PAAD, and THCA, suggesting that KIF2C may exerts exert an immunosuppressive effect in these tumors and that targeting KIF2C can achieve better immunotherapy outcomes. The gene discussed is KIF2C; the disease is bladder transitional cell carcinoma.