Studies have revealed that BRCA1/2 carriers possess no change or an even further decrease in breast cancer risk while using short-term HRT to control symptoms following surgical menopause (Eisen et al., 2008; Domchek et al., 2011; Kotsopoulos et al., 2016; Gordhandas et al., 2019). Here, BRCA1 is linked to breast carcinoma.