What’s more, it was reported that MLN4924 could inhibit the ubiquitination of Lats1 and 2 mediated by CRL4DCAF1, thereby inducing the phosphorylation and inactivation of YAP which led to the inhibition of proliferation in malignant pleural mesothelioma (Cooper et al., 2017). The gene discussed is LATS1; the disease is malignant pleural mesothelioma.