YAP1 and malignant pleural mesothelioma: What’s more, it was reported that MLN4924 could inhibit the ubiquitination of Lats1 and 2 mediated by CRL4DCAF1, thereby inducing the phosphorylation and inactivation of YAP which led to the inhibition of proliferation in malignant pleural mesothelioma (Cooper et al., 2017).