Top 5 genes with increased expression involved in the angiogenesis were ZNF519 (Zinc Finger Protein 519), UTRN (Utrophin), CSPG4 (Chondroitin Sulfate Proteoglycan 4), SMEK1 (also named PPP4R3A, Protein Phosphatase 4 Regulatory Subunit 3A) and VEGFC, while ALDH1A2, GLRA1 (Glycine Receptor Alpha 1), DPYS (Dihydropyrimidinase), NBPF10 (Neuroblastoma Breakpoint Family Member 10) and SYNPR (Synaptoporin) were the top 5 downregulated genes associated with the tumour angiogenesis. This evidence concerns the gene PPP4R3A and neoplasm.