In colon cancer, it was able to directly downregulate DIckkopf-3 (Dkk-3) with the help of extracellular vesicles (EVs) to promote angiogenesis, upregulate the endothelial cell cycle, and promote mitosis in endothelial cells to induce angiogenesis [35]. The gene discussed is DKK3; the disease is colonic neoplasm.