APP and Cognitive impairment: For example, the APP/PS45 murine model of AD exhibits cognitive deficits, as well as increased expression of APP, BACE1, Aβ1–40, and Aβ1–42, and increased neuritic plaque formation within the hippocampus, following experimenter-administered, binge-like, alcohol exposure during the adolescent/early adult period of development (Ledesma et al., 2020).