While the locus coeruleus (LC) is now known to be the first site of pathological tau accumulation (Braak et al., 2011), cortical regions associated with high metabolic activity, such as the default mode network, including the entorhinal cortex and hippocampus, are early targets of network abnormalities in Alzheimer's disease (AD) (Reiman et al., 2012; Vogel et al., 2020). Here, MAPT is linked to Alzheimer disease.